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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR2A
All Species:
15.45
Human Site:
S305
Identified Species:
34
UniProt:
P28223
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28223
NP_000612.1
471
52603
S305
S
I
H
R
E
P
G
S
Y
T
G
R
R
T
M
Chimpanzee
Pan troglodytes
Q5IS66
458
51816
I303
P
R
G
T
M
Q
A
I
N
N
E
R
K
A
S
Rhesus Macaque
Macaca mulatta
P50128
471
52585
S305
S
I
H
R
D
P
G
S
Y
T
G
R
R
T
M
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P35363
471
52823
S305
S
I
H
R
E
P
G
S
Y
A
G
R
R
T
M
Rat
Rattus norvegicus
P14842
471
52831
S305
S
I
H
R
E
P
G
S
Y
A
G
R
R
T
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514168
468
52300
L305
S
L
H
R
D
L
G
L
S
G
R
R
T
M
Q
Chicken
Gallus gallus
XP_425628
468
52653
T303
S
L
N
R
D
M
G
T
S
G
R
R
T
M
Q
Frog
Xenopus laevis
Q91559
425
47998
E274
I
P
R
L
Y
E
Q
E
G
I
Y
C
L
E
D
Zebra Danio
Brachydanio rerio
Q8JG70
408
46180
R257
N
S
S
E
S
A
Q
R
Q
E
E
L
D
D
I
Tiger Blowfish
Takifugu rubipres
P79748
379
42283
K228
A
A
R
S
R
I
F
K
T
P
S
Y
S
G
K
Fruit Fly
Dros. melanogaster
P41596
511
56152
C335
G
I
Y
C
R
L
Y
C
Y
A
Q
K
H
V
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.1
99.1
N.A.
N.A.
91.5
91.3
N.A.
79.4
76.8
28.8
21.8
24.4
27.7
N.A.
N.A.
N.A.
Protein Similarity:
100
65.3
100
N.A.
N.A.
95.3
95.1
N.A.
87.4
85.5
47.5
38.6
42.4
47.9
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
N.A.
N.A.
93.3
93.3
N.A.
33.3
26.6
0
0
0
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
N.A.
N.A.
93.3
93.3
N.A.
46.6
53.3
0
13.3
6.6
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
0
10
10
0
0
28
0
0
0
10
0
% A
% Cys:
0
0
0
10
0
0
0
10
0
0
0
10
0
0
0
% C
% Asp:
0
0
0
0
28
0
0
0
0
0
0
0
10
10
10
% D
% Glu:
0
0
0
10
28
10
0
10
0
10
19
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
10
0
0
0
55
0
10
19
37
0
0
10
0
% G
% His:
0
0
46
0
0
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
10
46
0
0
0
10
0
10
0
10
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
0
10
10
0
19
% K
% Leu:
0
19
0
10
0
19
0
10
0
0
0
10
10
0
0
% L
% Met:
0
0
0
0
10
10
0
0
0
0
0
0
0
19
37
% M
% Asn:
10
0
10
0
0
0
0
0
10
10
0
0
0
0
0
% N
% Pro:
10
10
0
0
0
37
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
19
0
10
0
10
0
0
0
19
% Q
% Arg:
0
10
19
55
19
0
0
10
0
0
19
64
37
0
0
% R
% Ser:
55
10
10
10
10
0
0
37
19
0
10
0
10
0
10
% S
% Thr:
0
0
0
10
0
0
0
10
10
19
0
0
19
37
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
10
0
10
0
46
0
10
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _